• four or more ear infections in one year
  • two or more sinus infections in one year
  • two or more months on antibiotics with no effect
  • two or more pneumonias within a year
  • failure of an infant to gain weight or grow normally
  • recurrent deep skin, tissue or joint infections
  • persistent thrush or fungal infection on skin
  • need for IV antibiotics to clear infections
  • two or more deep seated infections including sepsis
  • family history of immunodeficiency
  • multiple cancers or autoimmune diseases